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New Tripeptide Controls Skin Oiliness in Just 4 Hours
07/01/2025 By Chemyunion
Oily skin affects around 35% of the global population, causing discomfort such as excessive shine, enlarged pores, and acne. Beyond physical impacts, excess sebum is also linked to emotional concerns like low self-esteem and frustration.
A Growing Market for Oily Skin Care
According to Mordor Intelligence, the global market for oil-control products is expected to grow at a CAGR of 4.8% between 2019 and 2024, driven by rising demand among both men and women. While female consumers still lead, the male segment is growing rapidly as men increasingly show interest in personal care.
Limitations of Current Solutions
Most actives on the market work by inhibiting the 5α-reductase enzyme, which converts testosterone into dihydrotestosterone (DHT), stimulating sebum production. However, studies show that this pathway may be less effective across certain age groups and conditions, and it limits use to younger individuals (up to 30 years old), when testosterone levels are higher.
A New Approach to Oil Control: Targeting the MC5R Receptor
Recent research points to the melanocortin 5 receptor (MC5R) as a new target for controlling sebogenesis. This receptor is present in sebaceous gland cells, and MC5R blockers have shown significant sebum-reducing effects, making it a promising alternative to treat oily skin at any age.
Peptid4® S-Control: Chemyunion’s Innovation for Oily Skin
With this in mind, Chemyunion developed Peptid4® S-Control, an innovative tripeptide that blocks the MC5R receptor, effectively controlling oiliness across both young and mature skin. The molecule was selected through in silico screening of over 300,000 compounds, with proven efficacy in both in vitro and in vivo tests.
• Mattifies and balances oily skin, revealing a natural appearance
• Suitable for all ages, including mature skin
• Immediate 15% reduction in oiliness after 4 hours
• 30% decrease in sebum production after 14 days
• Visibly reduced pores
Efficacy Demonstration
In vitroIn vitro test – Inhibition of lipogenesis in human sebocytes
After 7 days of treatment with Peptid4® S-Control, a significant reduction in sebum production was observed, confirmed by immunofluorescence imaging.
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Visual Results – Before and After (D0 and D14)
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Figure 5: Photographs showing the reduction and control of skin oiliness in the volunteer before (D0) and after (D14) treatment with 1% Peptid4 S-Control.